What is OpenTOPAS?

The NIH-funded TOPAS project made radiation therapy simulations using the Monte Carlo method easily accessible for the radiotherapy community. This repository brings the code to a new, truly open release stage called OpenTOPAS.

OpenTOPAS wraps and extends the Geant4 Simulation Toolkit to provide an easier-to-use application for the medical physicist. The parameter control system lets physicists assemble and control a rich library of simulation objects—geometry components, particle sources, scorers—without writing C++ or knowing Geant4 internals. Visit the User Guide for deeper dives.

The project was originally created out of an NIH-funded collaboration of Massachusetts General Hospital, University of California San Francisco, and SLAC National Accelerator Laboratory. Today, the UCSF and MGH teams continue to maintain and expand OpenTOPAS in partnership with the Monte Carlo community.

OpenTOPAS supports simulation of medical applications of ionizing radiation with the Monte Carlo method. Free availability is intended to aid research by medical physicists, radiobiologists, and clinicians across all radiotherapy modalities. New users should review the key publications to explore its potential.

Mission

Deliver a validated, community-supported Monte Carlo framework that enables accurate and efficient radiation therapy research.

Why Open

Full open access allows advanced users to extend the platform in C++ while benefiting from the OpenTOPAS parameter system and Geant4 flexibility.

Focus Areas

Proton and conventional radiotherapy, LET / RBE modelling, optical photon transport, dosimetry detectors, and radiopharmaceutical therapy.

Collaborators

OpenTOPAS is jointly maintained by interdisciplinary teams at the University of California San Francisco and Massachusetts General Hospital / Harvard Medical School. Each site contributes physics leadership, code development, validation, and user support.

University of California San Francisco

Core Maintainers

  • Bruce Faddegon (PI 2018-2024)
  • José Ramos-Méndez
  • Thongchai Masilela
  • Naoki D-Kondo
  • Ramon Ortiz

Massachusetts General Hospital
Harvard Medical School

Core Maintainers

  • Harald Paganetti (PI 2009-2016)
  • Jan Schuemann
  • Alejandro Bertolet
  • Victor V. Onecha
  • Wook-Geun Shin

Former Contributors · UCSF

  • Daren Sawkey
  • Jhonatan Carrasco Hernandez
  • Jungwook Shin
  • Kyungdon Choi
  • Lucas Burigo
  • Pierluigi Piersimoni

Former Contributors · MGH / Harvard

  • Aimee McNamara
  • Alejandro Carabe-Fernández
  • Andrea Attili
  • David Hall
  • David J Carlson
  • Giulia Tamborino
  • Hongyu Zhu
  • Hoyeon Lee
  • Hsiao-Ming Lu
  • Ilaria Rinaldi
  • Isaac Meyer
  • Jungwook Shin
  • Kira Grogg
  • Lisa Polster
  • Mauro Testa
  • Nils Peters
  • Robert Stewart
  • Wonmo Sung
  • Yizheng Chen